Macropores and Micropores and their role in new bone formation

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The art of bone regeneration

Synthesis

  • Chemical synthesis of calcium and phosphate salts under controlled temperature and pressure
  • Controlled synthesis forms precise ratios of hydroxyapatite (60%) and beta calcium phosphate (40%) ensuring quality and homogeneity

Sublimation

  • Sublimation under controlled temperature and pressure creates an even distribution of macropores in the graft when porogen converts into a gas and evaporates

Sintering

  • Sintering is performed at an ultra low temperature ensuring the graft forms and maintains micropores, while preventing fusion of pores

Macropores and Micropores

  • Evenly distributed macropores ensure effective cell colonisation and vascularisation
  • Evenly distributed micropores ensures effective permeability and healthy bone regeneration
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Bone regeneration

Step 3 – Ions release

As healing begins, the graft dissolves and releases Ca2+ and PO43- ions

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Bone Regeneration

Step 5 – Stem cells adhesion

Localised stem cells are attracted to the newly formed bone crystals

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Bone Regeneration

Step 9 – Bone synthesis

Osteoblasts synthesise the surface by depositing collagen and non-collagen proteins

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Bone Regeneration

Step 10 – New bone formation

Blood vessels further nourish the surface and osteoblasts mature into osteocysts: forming new bone

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