Application of eCOO® Technology
CO2 enters a supercritical state when both the temperature and pressure simultaneously exceed the critical point of 31o C and 73 atm, respectively. In this state CO2 has both gas- and liquid-like properties, providing the ideal conditions for cleaning a wide variety of tissues from both human and animal origins (allografts and xenografts). scCO2 can penetrate tissue like a gas and dissolve materials like a liquid.
By regulating pressure and temperature, the solvent strength can be adjusted to simulate a wide range of organic solvents. This dissolving power can be applied to purify and sterilize different types of tissues.
Leader Biomedical has successfully applied eCOO® Technology to process human-derived cancellous and cortical bone, and tendons for over 10 years in Europe. eCOO® Technology has also been used to develop a dental membrane, derived from porcine tissue, for applications in guided bone and tissue regeneration. We have several other pipeline products, including acellular human dermis and porcine corneas, intended for use in dermal and corneal transplants.